Where and How is Human Growth Hormone (HGH) Produced?

Human growth hormone (HGH), is one of the initiators and controllers of physical and psychological processes that happen in our body.

If you’ve listened closely in science and biology class, you’d remember a funny thing about the endocrine system. For those who forgot, the endocrine system is a part of the body (like the neurological system, or digestive system) that is in charge of excreting various hormonal compounds into the body to give other organs the chemicals and signaling they need to work well.

The endocrine system consist of:

  • hypothalamus.
  • pituitary.
  • thyroid.
  • parathyroids.
  • adrenals.
  • pineal.
  • testes or ovaries.

The primary endocrine gland is the pituitary, a small nut-like gland that is nested in the center of our brain, just below the hypothalamus. The role of this gland kind of fits well with the location it is placed – it is the “head” of the endocrine system.

The pituitary gland produces and excretes several different hormones that oversee, or better, initialize and control the production of hormones in other glands in our body. The hormones it produces can stimulate other organs and metabolic processes, and they can induce the production of other hormones which together work for the betterment of our organism.

Even though it is placed in our head, the pituitary gland is not exactly a part of our nervous system, although it’s not exactly true that it isn’t. The pituitary gland communicates with other parts of the body through the hormones it produces and it oversees the healthy functioning of these parts of the body. These include the digestive tract, blood vessels and heart, muscle function and growth, genital function, thyroid, and adrenal function, even liver.

Indirectly, the function and hormone production of the pituitary gland eventually even affects our brain, either by the hormones that it produces on its own or by the hormones other glands produce by its order. For example, the adrenal gland can produce adrenaline which will make us feisty, or estrogen and testosterone which will either make us more interested in nail polishing or blade honing.

While it is in charge of healthy brain and body development, it is controlled by the brain itself, namely the hypothalamus, which produces chemical triggers that start or stop certain hormone production.

The Role of HGH

As you could imagine from this much, the pituitary gland produces human growth hormone. With HGH the body can do a lot because this stuff affects so many body processes.

For example, it is a vital part and triggers body growth. HGH is THE hormone that helps children grow into a size of an adult. Deficiencies in HGH can lead to slower and lesser growth, and the excess of this hormone can lead to gigantism in adulthood. The growth plan is dictated by several processes and in the vast majority of cases, these processes seal the growth somewhere in adulthood. So, there is no way to grow larger after these processes have ended.

In adulthood the production of HGH doesn’t stop, it just gets weaker little by little, until old age kicks in and it gets really low. In the meantime, HGH is in charge of various metabolic processes that maintain our body’s normal function.

One of these processes is the healthy development and maintenance of bone tissue. Through HGH the bones stay strong and sturdy. The same goes for our muscles. HGH is in charge of the creation of various proteins that also go into our muscles, so it’s in charge of maintaining and increasing the lean mass of our muscular system.

Okay, HGH is building, but it’s doing way more than that. It is involved in lipid metabolism as well, as it breaks down lipids so that the body can use energy from them, and then it’s involved in safely removing the side products from the bloodstream, along with triglycerides.

If you ever wondered why we need to take in our electrolytes regularly, you should know that we’d need to take much more if there wasn’t for HGH – this hormone regulates the retention of some of the most precious compounds within the body, like phosphate, sodium, etc. Without it, we’d need Gatorade much more often.

How pituitary gland doses HGH

The peculiar thing about HGH is that it is not constantly produced, but it’s rather produced in bursts. These bursts come several times during the day and it depends on the hypothalamus. The hypothalamus produces a hormone that triggers the pituitary gland to produce HGH in specific parts of the day (when sleeping for example).

Another way to trigger HGH production is during stress and physical strain. The body is then asked for better sugar metabolism and body rebuilding, so HGH is produced and released.

What Kind Of Peptide Is TB 500?

TB-500 is a synthetic peptide of the naturally occuring healing protein present in about all human and mammalian cells known as Thymosin Beta 4 (TB4). TB 500 is thought to have beneficial effects on wound healing, injury recovery, flexibility, and inflammation. Research indicated the effects of TB 500 are on blood cell and blood vessel development, cellular differentiation, and cell migration. The healing capability is due in large from the peptide’s regulation of actin, a cell building protein essential to healing and wound repair.

TB 500 is produced in the thymus gland and is found in high concentrations in wound fluids. Research demonstrates it has wound healing properties in addition to healing and repair of skin, cornea, and heart.

TB 500 is a naturally occurring peptide also found in high concentrations in blood platelets. TB-500 peptides for research are not growth factors; rather major actin regulating protein peptides. TB 500 plays an important role in protection, regeneration and remodeling of injured and/or damaged tissues. The gene that codes for Thymosin Beta-4 was noted in a study to be one of the first to be stimulated after an incident of injury.

Present in almost all human and animal cells, Thymosin Beta 4 is naturally occurring wound healing peptide. TB 500 , a synthetically made version of TB4 that facilitates comparable healing and recovery by helping building new blood vessels, muscle tissue fibers, blood cells, and facilitating cell migration. For a stressed and injured person, TB 500 can offer an extremely desirable wound healing effects.

No Horsing Around

TB-500 is a synthetic version of Thymosin Beta 4, a protein peptide that occurs naturally in the bodies of both animals and humans. Although TB-500 is available for research purposes, it is commonly used by many veterinarians who conduct clinical trials using TB-500 on horses. It is used to help promote healing from injury and reduce recovery time.

Dr. Allan Goldstein formulated thymosin alpha 1, in order to increase immune cell activity and subsequently thymosin bta 4 or TB-500, in order to accelerate healing and wound repair in animals, such as horses and ?

In racehorses TB 500 has shown significant reductions of inflammation and the inhibition or reduction of adhesions from injury.

The human use of thymosin began in 1974, with the first reported case being a young girl who was injected with thymosin due to a non functioning thymus gland. Since then, an increasing number of athletes and biohackers have been using thymosin all for the very same reasons of repair, reduction of inflammation and to speed up recovery.

Revitalizing Our Lives With Epitalon

Epitalon, also known as Epithalone or Epithalon, is a synthetic version of Epithalamin, a polypeptide naturally produced in the pineal gland.

The Epitalon peptide was discovered many years back by the Russian scientist Professor Vladimir Khavinson[i]. He carried out epitalon-related research for the following 35 years in both animal and human trials.

Primarily, the role of Epitalon is to increase natural production of telomerase. Telomerase is a natural enzyme that enables cells to reproduce telomeres – the protective parts of our DNA. In turn, this promotes the replication of DNA in order for the body to grow new cells and rejuvenate the old cells.

Younger people produce more telomerase than older people. In addition, they produce longer telomeres which leads to better cell health and replication.

As people age, telomerase production decreases and subsequently leads to cell replication decline. That’s where Epitalon comes in.

What Does Epitalon Do?

Epitalon definition: a mini protein that stimulates the production of telomerase.

How does Epitalon work? It works by regulating metabolism, heightening sensitivity of hypothalamus, stabilizing the function of the anterior pituitary and regulating melatonin levels in the body.

Epithalon peptide[ii] has a unique make-up of organisms determined by double-stranded DNA in the nucleus of the cells. At the tip of those DNA strands, you’ll find telomeres. They are responsible for preventing genetic information loss resulting from chromosome-shortening which happens with every cell separation.

Each time a cell separates, its replication is incomplete and consequently, telomeres get shorter. The more this happens, the more the telomeres shorten.

Numerous studies show that this shortening is linked to a slew of age-related diseases including cardiovascular disease and even early mortality in elderly people.

Known as the Epitalon fountain of youth due to its longevity effects, a high level of Epitalon results in overall wellness and wellbeing.

Effects of Epitalon

According to many studies[iii] conducted on both animals and humans, Epitalon is a substance biologically identical to the one produced by the human body. It can set the biological body clock of cells to zero in order for the cells to regain the reestablishment of optimal organ function and repair the body’s tissues.

Epitalon is a biopeptide created from four gero-protective amino acids (tetrapeptide: L-alanyl-l-glutamyl-l-asparagyl-glycine), which can be administered orally, intra-nasally, parenterally, sublingually, and also topically.

Russian researchers have discovered a lot about epithalon in recent years. For instance, they now know that it can reactivate telomerase production in cells. Furthermore, they know that it can also rejuvenate the whole body and promote health. They’ve even discovered that it can address the source of ageing.

Benefits of Epitalon Peptide

Scientific research proves that there are a number of Epitalon benefits. In short, these are the beneficial health effects of Epitalon peptide:

  • Increases longevity and human lifespan
  • Prevents age-related diseases such as dementia, heart disease, and cancer
  • Promotes deeper sleep
  • Improved skin health
  • Strengthens muscle cells
  • Speeds up healing
  • Reduces lipid oxidation and reactive oxygen species
  • Increases resistance to emotional stress
  • Stabilizes melatonin levels in elderly people

Of course, robust research must be carried out on this protein in order to fully understand its full affects. However, from what scientists have uncovered about epithalon, it seems likely that it will soon be available for human use to treat and cure a number of health issues. Remarkably, scientists believe that Epitalon could soon be used as a treatment and a preventative medicine against cancer.

To further understand the health benefits of Epitalon peptide, we’re going to take a deeper look at its benefits and full scope of potential uses.

Epitalon Anti-Aging Effects

In 1992, Professor Vladimir Dilman and Dr. Ward Dean co-authored a paper entitled “The neuroendocrine theory of aging and degenerative disease,” which showed that biopeptide epitalon can increase the lifespan of rats by 25%.

These findings were then confirmed by various subsequent studies carried out by Professor Vladimir Khavinson, President of the St Petersburg Institute of Bio-regulation.

As discovered by these researchers, Epitalon increases lifespan thanks to its ability to connect several amino acids by peptide bonds. This can also stimulate brain activity and reduce tumor formations.

After 15 years of clinical observation, Khavinson’s research on elderly individuals showed that biopeptides significantly improved physiological function and decreased mortality by approximately 50%.

He also demonstrated that the epithalon biopeptide DNA interactions could control genetic functions and consequently successfully extend life expectancy.

Research shows that mice given Epitalon from the age of three months until their natural death increased their lifespan compared to mice given placebo. Epitalon treatment also lowered the frequency of chromosome abnormalities in the subjects’ bone marrow cells. Treatment with Epitalon also prevented leukaemia development in mice. Overall, the results of the study suggest that this peptide offers a powerful anti-aging effect and is safe for long-term use.

Numerous animal studies show that taking Epitalon results in the following effects:

  • Regulated production of cortisol and melatonin in aging monkey, helping to stabilize the rhythm of cortisol secretion.
  • Protected reproductive system and corrected impairment in the reproductive systems of rats.
  • Preserved structure of the retina in retinitis pigmentosa.
  • Inhibited proliferation of colon tumors in rats.

Epitalon Skin Effects

In addition to its anti-aging effects, Epitalon promotes better skin health.

Research by Dr Khavinson shows that epithalon can activate the cells[iv] responsible to repairing and maintaining the extracellular matrix that keeps skin healthy and youthful. The extracellular matrix is where collagen and elastin can be found – the two anti-aging powerhouses.

While there are a number of skin aging creams that claim to strengthen collagen in the skin, they do not penetrate the skin as deeply as Epitalon. Epithalon penetrates the cells themselves and promotes both growth and development of the fibroblasts that make proteins like collagen. In turn, this leads to optimum skin regeneration.

But it’s not just the vanity side of aging that epithalon peptide helps. It can also ward off disease, infection and damage. Aged skin is prone to tears and being brittle. Epitalon used on the skin can ward off those symptoms.

Epitalon for Retinitis Pigmentosa

Retinitis pigmentosa is a degenerative eye disease that leads to the degeneration of the rods in the retina. Rods are a type of receptor in the eye that convert light into chemical signals. In a clinic trial, research showed that Epitalon improved degenerative damage to the retina caused by the condition.

In studies on rats, Epitalon advances the function of retinal cells by preventing degeneration and preserving the rod structure.

As per a study on humans and rats, it proves that Epitalon is an effective treatment for retinitis pigmentosa. Still, further research is needed to confirm the findings.

Epitalon Sleep Effects

Epitalon can allegedly correct circadian rhythms. In case you are wondering, what are circadian rhythms, let us explain.

Essentially, circadian rhythms are mental, physical and behavioral changes that follow a daily cycle. Circadian rhythms respond mainly to light and darkness, which is why sleeping at night and being awake in the day is a good example of a light-related circadian rhythm. Nearly all living things have them – humans, animals, plants and even tiny microbes.

However, as humans age, those rhythms get disrupted and less prominent, due to decreased melatonin secretion.

In a small study on 14 elderly people[v], epitalon significantly improved melatonin production. It also altered its cycle to mimic those of young people.

Another study on aging monkeys also showed how Epitalon stimulated evening melatonin secretion and corrected the biological rhythm.

And because they determine our sleep patterns, it appears clear that Epitalon improves sleep dramatically in the process. Thus, Epitalon supplementation may improve the overall sleep quality and patterns of users.

Epitalon for Cancer

Epitalon research is still mainly in the animal stage and further human studies are required in order to better understand this peptide. However, research shows that Epitalon as a cancer treatment and for cancer prevention can be extremely effective. Of course, you should not attempt to replace conventional cancer therapies with this protein. Still, it is interesting to see how beneficial its effects are on a number of health conditions.

According to studies on rats, Epitalon peptide increases lymph flow and apoptosis while slowing down cancer growth.

In mice with mammary tumors, Epitalon reduced the number of mice with multiple tumors and reduced the maximum size of the tumors. Researchers also learned that peptide Epitalon decreased the expression of certain genes that can play a key role in the development of certain cancers such as breast cancer in both mice and humans.

Meanwhile, an additional study in mice found that Epitalon treatment reduced the number of mice with cancerous tumors. It also prevented cancer from moving to another location in the body — most interestingly, in all of the treated mice. As for the mice that did not receive the Epitalon administration, metastases were observed in 3 out of the 9.

How Is Epitalon Used?

Epitalon is typically administered via intravenous or intramuscular injection. It can also be administered transdermally.

While many results of Epitalon are promising and certainly show a lot of beneficial effects, the majority of research has been conducted in animals. In other words, Epitalon human research remains largely unresearched.

For this reason, Epitalon is not FDA approved. That doesn’t mean it is dangerous to use, but it does mean it hasn’t yet received the sufficient human research needed to approve it for human consumption.

Overall, Epitalon antiaging effects especially look interesting and indeed, promising. Clearly the studies show how effective Epitalon is for increasing lifespan and promoting youthfulness. It also appears to be a promising cancer prevention drug.

Side Effects of Epitalon

According to over 100 scientific studies on Epitalon, there were no adverse reactions to this peptide. Of course, as with all drugs, Epitalon side effects may occur in certain individuals, which is why you should proceed with caution. If adverse effects do occur, immediately stop using.

Currently not yet approved by the FDA, Epitalon should only be purchased and used by scientific professionals for research purposes only.

Fortunately, it is considered a safe drug with no dangerous side effects. Nevertheless, the research on Epitalon continues in order to ensure its full safety and scope of benefits.

Author info: The information provided in this article was taken from studies carried out by recognized researchers including Anisimov, Vladimir N., and Vladimir Kh. Khavinson, Frolov, D. S., D. A. Sibarov, and A. B. Vol’nova, Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., Sinjari, B., Chalisova, N. I., N. S., Zhekalov, A. O. Orlova, G. A. Ryzhak, Shatilo, and L. V. Magdich.

References

[i] Anisimov, Vladimir N., and Vladimir Kh. Khavinson. “Peptide Bioregulation of Aging: Results and Prospects.” Biogerontology 11, no. 2 (October 15, 2009): 139–149. doi:10.1007/s10522-009-9249-8.

[ii] Frolov, D. S., D. A. Sibarov, and A. B. Vol’nova. “Altered Spontaneous Electric Activity Detected in Rat Motor Neocortex after Intranasal Epitalon Infusions.” PsycEXTRA Dataset (2004). doi:10.1037/e516032012-081.

[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules, 25(3), 609. doi:10.3390/molecules25030609

[iv] Chalisova, N. I., N. S. Linkova, A. N. Zhekalov, A. O. Orlova, G. A. Ryzhak, and V. Kh. Khavinson. “Short Peptides Stimulate Cell Regeneration in Skin During Aging.” Advances in Gerontology 5, no. 3 (July 2015): 176–179. doi:10.1134/s2079057015030054.

[v] Korkushko, O. V., V. Kh. Khavinson, V. B. Shatilo, and L. V. Magdich. “Effect of Peptide Preparation Epithalamin on Circadian Rhythm of Epiphyseal Melatonin-Producing Function in Elderly People.” Bulletin of Experimental Biology and Medicine 137, no. 4 (April 2004): 389–391. doi:10.1023/b:bebm.0000035139.31138.bf.Cite this article as: Research Peptides Scientists, “Epitalon (Epithalon) 10mg,” in ResearchPeptides.net, June 29, 2020, https://researchpeptides.net/product/peptides/epitalon-epithalon-10mg/.

Epitalon Research Peptides Scientists

Benefits of CJC – 1295 / Ipamorelin Over Time

Peptide research is proving that short chain amino acids like CJC-1295 combined with Ipamorelin are about to become the most effective anti-aging and weigh-loss treatments in the history of mankind.

These two peptides have already proven to be game changers for inflammatory conditions, energy deficiencies, mood disorders, and sleep issues. But, now research scientists and cutting edge medical doctors feel their anti-aging and weight loss benefits are so incredibly effective that they will soon become the #1 go-to weight loss and anti-aging treatments in the 2nd half of the 21st century.

Sometime before midnight as well as the early morning Growth hormone is released into the bloodstream from the anterior pituitary gland.

Our body’s natural growth hormone levels peak when we are about 20 years old and slowly decrease but stays close to to that level until around 30 years old at which time the HGH level begins to decrease at a rate of about 15% a year.

As the body ages, both men and women tend to gain weight, lose energy, and decrease muscle mass. This is due to our natural growth hormone levels that have decreased year over year as we age.

How long does it take for CJC-1295 / Ipamorelin to work?

Research shows CJC-1295/ Ipamorelin short term (3-6 months) has proven to have fat loss benefits and provide overall improvements in body composition. CJC-1295/Ipamorelin increases fat metabolism, so when aging and low HGH levels are present and this starts to become a factor in a person’s ability to lose weight, these peptides can create a more efficient and sometimes faster process of loosing adipose tissue.

WHAT IS THYMOSIN BETA 4?

Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin beta 4, is an actin, a cell building protein. One of the main mechanisms of action of Thymosin Beta-4 is its regulation of Actin. This cell-building protein is an essential component of cell structure and movement which leads to its role in tissue repair. Tβ 4 has been found to play an important role in protection, regeneration, and remodeling of injured or damaged tissues. After an injury, Tβ 4 is released by platelets and numerous other types of cells to protect the most damaged cells and tissues and to reduce inflammation and microbial growth.

Benefits of Thymosin beta 4:

  • Calms muscle spasms
  • Enhances muscle tone
  • Increased exchange of substances between cells
  • Encourages tissue repair
  • Stretches connective tissue
  • Helps maintain flexibility
  • Reduced inflammation of tissue in joints
  • Encourages the growth of new blood cells in tissue
  • Increased endurance and strength
  • Prevents the formation of adhesions and fibrous bands in muscles, tendons, and ligaments

Recent studies have revealed that the first gene to be upregulated after an injury is a Tβ4 gene. As the body begins the recovery process, Tβ4 aids in the creation of new vessels in the injured area, which carry blood, nutrients, and reparative substances to the site. Tβ4 also has anti-inflammatory properties and works to decrease the amount of inflammatory substances, called cytokines. Inflammation plays a large role in many of the symptoms associated with a number of other conditions (i.e., Lyme disease, CFS, FM, autoimmune diseases, infections, etc.), making the potential impact of Tβ4 quite extensive.

The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following a heart attack due to its cardio and neuroprotective effects.

Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable peptide.

Fighting Off The Effects Of Aging The Epitalon Peptide

Composed of 4 amino acid chains Epitalon is a synthetic derivative of epithalamin and a potential modulator of telomerase, the enzyme that maintains and protects the telomere caps at the ends of chromosomes (strands of DNA). Research suggests that epithalon induces telomere elongation and may fight off the effects of aging as a result.

The Epitalon peptide has proven to not only produce a relatively large amount of new telomerase, they produce longer telomeres strands which are in the better cell health and replicate faster.

Introducing the Epitalon peptide into the body appears to stop the degeneration of the telomeres, which naturally happens and is one of the main reasons humans age and their health declines.

In the next article we will be investigating how Epitalon and another peptide play out a symbiotic role in regulating metabolism, increasing the sensitivity of hypothalamus to its natural hormonal levels, normalizing the function of the anterior pituitary and regulating the levels of gonadotropins and melatonin in the body.

Please direct your questions to the comments section or on my facebook messenger. Blessings, Bobby

BPC-157 Superman’s Secret To Almost Instant Healing

With all the recent questions about peptides, I felt that I should clarify that peptides are simply a sequence of amino acids. In the 21st century we will continue to see further breakthroughs in way we will use peptides to optimize our health and healing and lifestyles.

I am particularly excited about BPC-157 and its wide array of health benefits, as it’s not simply a vascular endothelial growth factor analog it is often misrepresented as; Rather than acting like a regular VEGF it will promote the complex physiological processes that occur during wound healing and tissue regeneration and repair – both inside and outside of the gastrointestinal tract. BPC-157 is proving to be a fascinating medical breakthrough for anyone who is interested in optimizing fat loss, strengthening, repairing and rebuilding muscle tissue, slowing the aging process, balancing and strengthening their immune system, healing stomach and intestinal issues, strengthening the heart muscle and insuring brain plasticity and ensuring neuroprotective health.

BPC-157 may promote the regeneration of the cells of the intestinal wall (intestinal health | Sikiric 2018)

BPC-157 may promote and accelerate muscle, tendon and bone healing (sports and other tissue and bone injuries | Brcic 2009, Krivic 2008, Sebecic 1999)

BPC-157 aids in the repair and replacement of atherosclerotic endothelial cells (cardiovascular health | Sikiric 2018)

BPC-157 promotes, optimizes and accelerates wound healing (skin health and organ damage | Huang 2015; Stupnisek 2015)

BPC-157 prevents and reverses lesions of the intestinal tract, liver, and even brain as they can occur in response to the (ab-)use of certain pain medications (general organ health | Drmic 2018) and the cardiovascular side effects of anti-psychotics (heart health | Strinic 2017)

BPC-157 heals (stress-induced) ulcers and fistulas as they are increasingly common due to our stressful (this refers to “stress” as general oxidative stress) lifestyles (GI health and beyond | Szabo 2017; Grgic 2016)

BPC-157 serves as a remedy for a plethora of central nervous system disorders that originate in the gut by (a) the local repair of the intestinal lining and (b) direct neuroprotective effects in the brain (brain & CNS health | Sikiric 2016)

BPC-157 can be paired with other peptides and compounds for maximum results:

  • Thymosin Alpha-1 and Thymosin Beta-4 are great for restoring the immune system and reducing inflammation.
  • PT-141 can be used to help with erectile dysfunction. [43]
  • RG3 and VIP are commonly incorporated in the treatment of Lyme and toxic mold syndrome (see my article on mold toxicity for more information on my treatment philosophy).
  • LL37 is a potent antimicrobial agent and can be a useful partner in wound healing.[44]
  • Pentosan Polysulfate Sodium Peptide (Elmiron) and AOD 9604 decrease pain receptors in the brain, which reduces the subjective perception of pain.
  • Melanotan is another peptide with potent anti-inflammatory activity. It targets the vagus nerve via the cholinergic pathway. The result is the removal of inflammatory molecules and calmer brain.

Please consult your health provider before researching or experimenting with ANY peptide or changing your medications. If you have had cancer or have cancer consult your oncologist before even considering peptide research.

Best Day Ever, Bobby